Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2012, Article ID 318621, 9 pages
http://dx.doi.org/10.1155/2012/318621
Research Article

Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis

1Department of Ophthalmology, Second University of Naples, 80100 Naples, Italy
2Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
3Department of Clinical, Public and Preventive Medicine, Second University of Naples, 80138 Naples, Italy

Received 28 August 2012; Revised 14 November 2012; Accepted 14 November 2012

Academic Editor: Fulvio D'Acquisto

Copyright © 2012 Rossi Settimio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Rossi, M. D'Amico, A. Capuano, M. Romano, P. Petronella, and C. Di Filippo, “Hyperglycemia in streptozotocin-induced diabetes leads to persistent inflammation and tissue damage following uveitis due to reduced levels of ciliary body heme oxygenase-1,” Mediators of Inflammation, vol. 2006, no. 4, Article ID 60285, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. C. N. Serhan, “Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways,” Annual Review of Immunology, vol. 25, pp. 101–137, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Fredman and C. N. Serhan, “Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution,” Biochemical Journal, vol. 437, no. 2, pp. 185–197, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. P. Sun, S. F. Oh, J. Uddin et al., “Resolvin D1 and its aspirin-triggered 17R epimer: stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation,” Journal of Biological Chemistry, vol. 282, no. 13, pp. 9323–9334, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Schwab, N. Chiang, M. Arita, and C. N. Serhan, “Resolvin E1 and protectin D1 activate inflammation-resolution programmes,” Nature, vol. 447, no. 7146, pp. 869–874, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Ariel, G. Fredman, Y. P. Sun et al., “Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression,” Nature Immunology, vol. 7, no. 11, pp. 1209–1216, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. E. L. Campbell, N. A. Louis, S. E. Tomassetti et al., “Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution,” FASEB Journal, vol. 21, no. 12, pp. 3162–3170, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. C. N. Serhan, N. Chiang, and T. E. Van Dyke, “Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators,” Nature Reviews Immunology, vol. 8, no. 5, pp. 349–361, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Ariel and C. N. Serhan, “Resolvins and protectins in the termination program of acute inflammation,” Trends in Immunology, vol. 28, no. 4, pp. 176–183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. Z. Xu, L. Zhang, T. Liu et al., “Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions,” Nature Medicine, vol. 16, no. 5, pp. 592–597, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. F. F. Behar-Cohen, M. Savoldelli, J. M. Parel et al., “Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis,” Investigative Ophthalmology and Visual Science, vol. 39, no. 6, pp. 897–904, 1998. View at Google Scholar · View at Scopus
  12. K. A. Kernacki and R. S. Berk, “Characterization of arachidonic acid metabolism and the polymorphonuclear leukocyte response in mice infected intracorneally with Pseudomonas aeruginosa,” Investigative Ophthalmology and Visual Science, vol. 36, no. 1, pp. 16–23, 1995. View at Google Scholar · View at Scopus
  13. D. O. Girgis, G. D. Sloop, J. M. Reed, and R. J. O'Callaghan, “A new topical model of Staphylococcus corneal infection in the mouse,” Investigative Ophthalmology and Visual Science, vol. 44, no. 4, pp. 1591–1597, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Yang, H. Jin, K. Liu, Q. Gu, and X. Xu, “A novel peptide derived from human pancreatitis-associated protein inhibits inflammation in vivo and in vitro and blocks NF-kappa B signaling pathway,” PLoS ONE, vol. 6, no. 12, Article ID e29155, 2011. View at Google Scholar
  15. C. N. Serhan and N. A. Petasis, “Resolvins and protectins in inflammation resolution,” Chemical Reviews, vol. 111, no. 10, pp. 5922–5943, 2011. View at Google Scholar
  16. M. Perretti and F. D'Acquisto, “Annexin A1 and glucocorticoids as effectors of the resolution of inflammation,” Nature Reviews Immunology, vol. 9, no. 1, pp. 62–70, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Rivière, L. Challet, D. Fluegge, M. Spehr, and I. Rodriguez, “Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors,” Nature, vol. 459, no. 7246, pp. 574–577, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Krishnamoorthy, A. Recchiuti, N. Chiang et al., “Resolvin D1 binds human phagocytes with evidence for proresolving receptors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 4, pp. 1660–1665, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Tian, Y. Lu, A. M. Sherwood, D. Hongqian, and S. Hong, “Resolvins el and dl in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions,” Investigative Ophthalmology and Visual Science, vol. 50, no. 8, pp. 3613–3620, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. M. N. Ajuebor, M. G. Swain, and M. Perretti, “Chemokines as novel therapeutic targets in inflammatory diseases,” Biochemical Pharmacology, vol. 63, no. 7, pp. 1191–1196, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. M. N. Ajuebor, L. Virág, R. J. Flower, M. Perretti, and C. Szabó, “Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation,” Immunology, vol. 95, no. 4, pp. 625–630, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. A. M. Vicente, M. I. Guillén, and M. J. Alcaraz, “Participation of heme oxygenase-1 in a model of acute inflammation,” Experimental Biology and Medicine, vol. 228, no. 5, pp. 514–516, 2003. View at Google Scholar · View at Scopus
  23. C. Cuello, D. Wakefield, and N. Di Girolamo, “Neutrophil accumulation correlates with type IV collagenase/gelatinase activity in endotoxin induced uveitis,” British Journal of Ophthalmology, vol. 86, no. 3, pp. 290–295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. S. A. Thorne, S. E. Abbot, C. R. Stevens, P. G. Winyard, P. G. Mills, and D. R. Blake, “Modified low density lipoprotein and cytokines mediate monocyte adhesion to smooth muscle cells,” Atherosclerosis, vol. 127, no. 2, pp. 167–176, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. J. He, A. H. Kakazu, N. G. Bazan, and H. E. P. Bazan, “Aspirin-triggered lipoxin A4 (15-epi-LXA4) increases the endothelial viability of human corneas storage in Optisol-GS,” Journal of Ocular Pharmacology and Therapeutics, vol. 27, no. 3, pp. 235–241, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. O. Odusanwo, S. Chinthamani, A. McCall, M. E. Duffey, and O. J. Baker, “Resolvin D1 prevents TNF-á-mediated disruption of salivary epithelial formation,” American Journal of Physiology, vol. 302, no. 9, pp. C1331–C1345, 2012. View at Google Scholar
  27. J. V. Forrester, H. Xu, T. Lambe, and R. Cornall, “Immune privilege or privileged immunity?” Mucosal Immunology, vol. 1, no. 5, pp. 372–381, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. V. Forrester, “Privilege revisited: an evaluation of the eye's defence mechanisms,” Eye, vol. 23, no. 4, pp. 756–766, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Willermain, J. T. Rosenbaum, B. Bodaghi et al., “Interplay between innate and adaptive immunity in the development of non-infectious uveitis,” Progress in Retinal and Eye Research, vol. 31, no. 2, pp. 182–194, 2012. View at Google Scholar
  30. M. Kogiso, Y. Tanouchi, Y. Mimura, H. Nagasawa, and K. Himeno, “Endotoxin-induced uveitis in mice. 1. Induction of uveitis and role of T lymphocytes,” Japanese Journal of Ophthalmology, vol. 36, no. 3, pp. 281–290, 1992. View at Google Scholar · View at Scopus
  31. P. G. McMenamin and J. Crewe, “Endotoxin-induced uveitis: kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body,” Investigative Ophthalmology and Visual Science, vol. 36, no. 10, pp. 1949–1959, 1995. View at Google Scholar · View at Scopus
  32. A. M. Avunduk, M. C. Avunduk, E. Oztekin, and A. K. Baltaci, “Characterization of T lymphocyte subtypes in endotoxin-induced uveitis and effect of pentoxifylline treatment,” Current Eye Research, vol. 24, no. 2, pp. 92–98, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Trinh, F. Brignole-Baudouin, A. Pauly, H. Liang, M. Houssier, and C. Baudouin, “Th1-and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis,” Molecular Vision, vol. 14, pp. 2428–2434, 2008. View at Google Scholar · View at Scopus
  34. T. J. Schall, J. Jongstra, B. J. Dyer et al., “A human T cell-specific molecule is a member of a new gene family,” Journal of Immunology, vol. 141, no. 3, pp. 1018–1025, 1988. View at Google Scholar · View at Scopus
  35. A. M. Krensky, Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit), R. G. Landes Co, 1995.
  36. A. Song, Y. F. Chen, K. Thamatrakoln, T. A. Storm, and A. M. Krensky, “RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes,” Immunity, vol. 10, no. 1, pp. 93–103, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Song, T. Nikolcheva, and A. M. Krensky, “Transcriptional regulation of RANTES expression in T lymphocytes,” Immunological Reviews, vol. 177, pp. 236–245, 2000. View at Google Scholar · View at Scopus
  38. B. L. Daugherty, S. J. Siciliano, J. A. DeMartino, L. Malkowitz, A. Sirotina, and M. S. Springer, “Cloning, expression, and characterization of the human eosinophil eotaxin receptor,” Journal of Experimental Medicine, vol. 183, no. 5, pp. 2349–2354, 1996. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Struyf, P. Menten, J. P. Lenaerts et al., “Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils,” European Journal of Immunology, vol. 7, pp. 2170–2178, 2001. View at Google Scholar
  40. H. Slimani, N. Charnaux, E. Mbemba et al., “Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages,” Biochimica et Biophysica Acta, vol. 1617, no. 1-2, pp. 80–88, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Fischereder, “Chemokines and chemokine receptors in renal transplantation—from bench to bedside,” Acta Physiologica Hungarica, vol. 94, no. 1-2, pp. 67–81, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Cocchi, A. L. DeVico, A. Garzino-Demo, S. K. Arya, R. C. Gallo, and P. Lusso, “Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells,” Science, vol. 270, no. 5243, pp. 1811–1815, 1995. View at Google Scholar · View at Scopus
  43. A. A. Maghazachi, A. Al-Aoukaty, and T. J. Schall, “CC chemokines induce the generation of killer cells from CD56+ cells,” European Journal of Immunology, vol. 26, no. 2, pp. 315–319, 1996. View at Publisher · View at Google Scholar · View at Scopus