Disruption of the <i>ECM33</i> Gene in <i>Candida albicans</i> Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis

<table>Interaction of <i>ECM33</i> mutants with EHOM and biofilm formation. Histological features of the EHOM following 24 h of exposure to each <i>C. albicans</i> strain. (a) Noninfected EHOM tissue; (b) infected with CAF2 strain; (c) RML1; (d) RML2; (e) RML3; (f) RML4 <i>C. albicans</i>. The noninfected EHOM (a) displays an epithelium (Ep) containing a stratum corneum layer (SC), a basal layer (BL), and a collagen-containing lamina propria (LP) populated with fibroblasts (arrows). Scale bars, 30 <i>μ</i>m. Representative photographs of three different experiments are shown (two EHOMs per experiment).</table>

Mediators of Inflammation

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Figure 2

Figure 2: Disruption of the <i>ECM33</i> Gene in <i>Candida albicans</i> Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis 

Figure 2 | Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis 