Disruption of the <i>ECM33</i> Gene in <i>Candida albicans</i> Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis

<table>LDH release following EHOM infection with <i>C. albicans</i> strains. Culture media were collected from the noninfected and infected EHOMs. Supernatants were used to assess LDH release by means of specific kits. Data are means + SD, <svg height="10.925" id="M13" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.012,-0,0,-.012,.062,5.525)"><use xlink:href="#x2217"></use></g><g transform="matrix(.012,-0,0,-.012,7.047,5.525)"><use xlink:href="#x2217"></use></g>
<g transform="matrix(.017,-0,0,-.017,14.65,13.688)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,30.187,13.688)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,44.874,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,53.033,13.688)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,56.909,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,65.068,13.688)"><use xlink:href="#x31"></use></g>
</svg> compared to the control (CAF2-infected EHOM).</table>

Mediators of Inflammation

fig4

Figure 4

Figure 4: Disruption of the <i>ECM33</i> Gene in <i>Candida albicans</i> Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis 

Figure 4 | Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis 