BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
Figure 1
Effect of BAY (BAY 11-7082) on the production of NO, TNF-α, and PGE2 in RAW264.7 and peritoneal macrophages, and cell viability. (a) Chemical structure of BAY. (b, c left panel, and d) Levels of NO determined by the Griess assay, TNF-α by ELISA, and PGE2 by EIA from culture supernatants of RAW264.7 cell (b and d) and peritoneal macrophages (c) treated with BAY (0 to 15 μM) in the presence or absence of LPS (1 μg/mL) for 6 h (TNF-α) or 24 h (NO and PGE2). (b and c right panel) Viability of RAW264.7 cells treated with BAY by MTT assays. * and ** compared to the control.
