Changes in the Th1 : Th2 Cytokine Bias in Pregnancy and the Effects of the Anti-Inflammatory Cyclopentenone Prostaglandin 15-Deoxy--Prostaglandin
Figure 5
Schematic proposal of the Th1 and Th2 balance and the role of CRTH2 and NF-κB. T-helper cell precursors are directed toward committed immunophenotype by the typical Th1 and Th2 interleukins, IFN-γ and IL-4, respectively. Infection or propregnancy hormones such as progesterone can further modulate the Th1/Th2 bias. Based upon our findings and those of others, we propose that 15dPGJ2 maintains a Th2 bias principally through the suppression Th1 interleukins through the inhibition of NF-κB.
