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Mediators of Inflammation
Volume 2012, Article ID 438912, 10 pages
http://dx.doi.org/10.1155/2012/438912
Research Article

Anti-Inflammatory and Antinociceptive Effects of Salbutamol on Acute and Chronic Models of Inflammation in Rats: Involvement of an Antioxidant Mechanism

1Department of Physical Medicine and Rehabilitation, Erzurum Regional Training and Research Hospital, 25240 Erzurum, Turkey
2Department of Pharmacology, Faculty of Pharmacy, Atatürk University, 25240 Erzurum, Turkey
3Department of Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey
4Department of Biochemistry, Faculty of Pharmacy, Atatürk University, 25240 Erzurum, Turkey

Received 1 December 2011; Revised 28 February 2012; Accepted 28 February 2012

Academic Editor: Tânia Fröde

Copyright © 2012 Hulya Uzkeser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Libby, P. M. Ridker, and A. Maseri, “Inflammation and atherosclerosis,” Circulation, vol. 105, no. 9, pp. 1135–1143, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. P. L. McGeer and E. G. McGeer, “Polymorphisms in inflammatory genes and the risk of Alzheimer disease,” Archives of Neurology, vol. 58, no. 11, pp. 1790–1792, 2001. View at Google Scholar · View at Scopus
  4. H. Suleyman, A. Albayrak, M. Bilici, E. Cadirci, and Z. Halici, “Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers,” Inflammation, vol. 33, no. 4, pp. 224–234, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. P. W. Thompson, L. Tee, J. McBride, D. Quincey, and G. S. Liddiard, “Long-term NSAID use in primary care: changes over a decade and NICE risk factors for gastrointestinal adverse events,” Rheumatology, vol. 44, no. 10, pp. 1308–1310, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Vanegas and H. G. Schaible, “Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord,” Progress in Neurobiology, vol. 64, no. 4, pp. 327–363, 2001. View at Google Scholar
  7. M. I. Diaz-Reval, R. Ventura-Martinez, M. Deciga-Campos, J. A. Terron, F. Cabre, and F. J. Lopez-Munoz, “Involvement of serotonin mechanisms in the antinociceptive effect of S(+)-ketoprofen,” Drug Development Research, vol. 57, no. 4, pp. 187–192, 2002. View at Publisher · View at Google Scholar
  8. R. Ventura-Martinez, M. Deciga-Campos, M. I. Diaz-Reval, M. E. Gonzalez-Trujano, and F. J. Lopez-Munoz, “Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat,” European Journal of Pharmacology, vol. 503, no. 1–3, pp. 43–48, 2004. View at Google Scholar
  9. I. Lizarraga and J. P. Chambers, “Involvement of opioidergic and α2-adrenergic mechanisms in the central analgesic effects of non-steroidal anti-inflammatory drugs in sheep,” Research in Veterinary Science, vol. 80, no. 2, pp. 194–200, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Suleyman, Z. Halici, E. Cadirci, A. Hacimuftuoglu, and H. Bilen, “Indirect role of β2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDs,” Journal of Physiology and Pharmacology, vol. 59, no. 4, pp. 661–672, 2008. View at Google Scholar · View at Scopus
  11. E. Cadirci, H. Suleyman, A. Hacimuftuoglu, Z. Halici, and F. Akcay, “Indirect role of β2-adrenergic receptors in the mechanism of analgesic action of nonsteroidal antiinflammatory drugs,” Critical Care Medicine, vol. 38, no. 9, pp. 1860–1867, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. E. R. Pettipher, J. D. Eskra, and J. M. Labasi, “The inhibitory effect of rolipram on TNF-α production in mouse blood ex vivo is dependent upon the release of corticosterone and adrenaline,” Cytokine, vol. 9, no. 8, pp. 582–586, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Szelenyi, J. P. Kiss, E. Puskas, M. Szelenyi, and E. S. Vizi, “Contribution of differently localized alpha(2)- and beta-adrenoceptors in the modulation of TNF-alpha and IL-10 production in endotoxemic,” Neuroimmunomodulation, vol. 917, no. 36, pp. 145–153, 2000. View at Google Scholar
  14. A. G. Nackley, K. S. Tan, K. Fecho, P. Flood, L. Diatchenko, and W. Maixner, “Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both β2- and β3-adrenergic receptors,” Pain, vol. 128, no. 3, pp. 199–208, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Pelegrini-da-Silva, M. C. Oliveira, C. A. Parada, and C. H. Tambeli, “Nerve growth factor acts with the β2-adrenoceptor to induce spontaneous nociceptive behavior during temporomandibular joint inflammatory hyperalgesia,” Life Sciences, vol. 83, no. 23-24, pp. 780–785, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Choucair-Jaafar, I. Yalcin, J. L. Rodeau, E. Waltisperger, M. J. Freund-Mercier, and M. Barrot, “β2-Adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment,” British Journal of Pharmacology, vol. 158, no. 7, pp. 1683–1694, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. I. Yalcin, L. H. Tessier, N. Petit-Demoulière et al., “Chronic treatment with agonists of β2-adrenergic receptors in neuropathic pain,” Experimental Neurology, vol. 221, no. 1, pp. 115–121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Yalcin, N. Choucair-Jaafar, M. Benbouzid et al., “β-2 adrenoceptors are critical for antidepressant treatment of neuropathic pain,” Annals of Neurology, vol. 65, no. 2, pp. 218–225, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. B. M. Prenner, “Role of long-acting β2-adrenergic agonists in asthma management based on updated asthma guidelines,” Current Opinion in Pulmonary Medicine, vol. 14, no. 1, pp. 57–63, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Baramki, J. Koester, A. J. Anderson, and L. Borish, “Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomer,” Journal of Allergy and Clinical Immunology, vol. 109, no. 3, pp. 449–454, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. G. W. Volcheck, P. Kelkar, K. R. Bartemes, G. J. Gleich, and H. Kita, “Effects of (R)- and (S)-isomers of β-adrenergic agonists on eosinophil response to interleukin-5,” Clinical and Experimental Allergy, vol. 35, no. 10, pp. 1341–1346, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. A. R. Leff, A. Herrnreiter, R. M. Naclerio, F. M. Baroody, D. A. Handley, and N. M. Muñoz, “Effect of enantiomeric forms of albuterol on stimulated secretion of granular protein from human eosinophils,” Pulmonary Pharmacology and Therapeutics, vol. 10, no. 2, pp. 97–104, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. W. Zhang, L. Fievez, E. Cheu et al., “Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats,” European Journal of Pharmacology, vol. 628, no. 1–3, pp. 171–178, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. G. B. Jemec, S. Ullman, M. Goodfield et al., “A randomized controlled trial of R-salbutamol for topical treatment of discoid lupus erythematosus,” British Journal of Dermatology, vol. 161, no. 6, pp. 1365–1370, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. B. M. Babior, R. S. Kipnes, and J. T. Curnutte, “Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.,” Journal of Clinical Investigation, vol. 52, no. 3, pp. 741–744, 1973. View at Google Scholar · View at Scopus
  26. J. I. Braga da Motta, F. Q. Cunha, B. B. Vargaftig, and S. H. Ferreira, “Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion,” British Journal of Pharmacology, vol. 112, no. 1, pp. 111–116, 1994. View at Google Scholar · View at Scopus
  27. D. Salvemini, Z. Q. Wang, D. M. Bourdon, M. K. Stern, M. G. Currie, and P. T. Manning, “Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema,” European Journal of Pharmacology, vol. 303, no. 3, pp. 217–220, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. O. Gualillo, S. Eiras, F. Lago, C. Diéguez, and F. F. Casanueva, “Elevated serum leptin concentrations induced by experimental acute inflammation,” Life Sciences, vol. 67, no. 20, pp. 2433–2441, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. J. W. Steinke and L. Borish, “Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists,” Respiratory Research, vol. 2, no. 2, pp. 66–70, 2001. View at Publisher · View at Google Scholar
  30. C. A. Winter, E. A. Risley, and G. W. Nuss, “Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs,” Proceedings of the Society for Experimental Biology and Medicine, vol. 111, pp. 544–547, 1962. View at Google Scholar · View at Scopus
  31. J. R. Fozard, F. Baur, C. Wolber, and S. P. Collingwood, “Inhibition by viozan of extravasation induced in rat trachea by capsaicin is mediated exclusively by β2-adrenoceptors,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 364, no. 6, pp. 570–572, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Tanaka, R. Yamagishi, M. Tsutsui et al., “Tissue- and dose-dependent alteration of stress-inducible proteins by β2-adrenoceptor agonist, salbutamol, in rats,” Journal of Toxicological Sciences, vol. 30, no. 4, pp. 305–314, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. W. H. Hsu and C. W. Cooper, “Hypercalcemic effect of catecholamines and its prevention by thyrocalcitonin,” Calcified Tissue International, vol. 19, no. 2, pp. 125–137, 1975. View at Google Scholar · View at Scopus
  34. C. Gopinath and W. A. Gibson, “Mesovarian leiomyomas in the rat,” Environmental Health Perspectives, vol. 73, pp. 107–113, 1987. View at Google Scholar · View at Scopus
  35. H. Suleyman, E. Cadirci, A. Albayrak et al., “Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather,” Pharmacological Reports, vol. 61, no. 3, pp. 514–519, 2009. View at Google Scholar · View at Scopus
  36. G. Ozbakis-Dengiz, Z. Halici, E. Akpinar, E. Cadirci, D. Bilici, and N. Gursan, “Role of polymorphonuclear leukocyte infiltration in the mechanism of anti-inflammatory effect of amiodarone,” Pharmacological Reports, vol. 59, no. 5, pp. 538–544, 2007. View at Google Scholar · View at Scopus
  37. H. Suleyman, E. Cadirci, A. Albayrak, and Z. Halici, “Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal inflammatory drug,” Current Medicinal Chemistry, vol. 15, no. 3, pp. 278–283, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. F. Odabasoglu, Z. Halici, A. Cakir et al., “Beneficial effects of vegetable oils (corn, olive and sunflower oils) and α-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats,” European Journal of Pharmacology, vol. 591, no. 1–3, pp. 300–306, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Albayrak, B. Polat, E. Cadirci et al., “Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats,” Pharmacological Reports, vol. 62, no. 1, pp. 113–119, 2010. View at Google Scholar · View at Scopus
  40. S. Shukla, A. Mehta, P. Mehta, S. P. Vyas, S. Shukla, and V. K. Bajpai, “Studies on anti-inflammatory, antipyretic and analgesic properties of Caesalpinia bonducella F. seed oil in experimental animal models,” Food and Chemical Toxicology, vol. 48, no. 1, pp. 61–64, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. L. O. Randall and J. J. Selitto, “A method for measurement of analgesic activity on inflamed tissue,” Archives Internationales de Pharmacodynamie et de Therapie, vol. 111, no. 4, pp. 409–419, 1957. View at Google Scholar
  42. H. Suleyman, Z. Halici, A. Hacimuftuoglu, and F. Gocer, “Role of adrenal gland hormones in antiinflammatory effect of calcium channel blockers,” Pharmacological Reports, vol. 58, no. 5, pp. 692–699, 2006. View at Google Scholar · View at Scopus
  43. A. Panthong, D. Kanjanapothi, T. Taesotikul, A. Phankummoon, K. Panthong, and V. Reutrakul, “Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre,” Journal of Ethnopharmacology, vol. 91, no. 2-3, pp. 237–242, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. H. Hosseinzadeh, M. Ramezani, and G. Salmani, “Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats,” Journal of Ethnopharmacology, vol. 73, no. 3, pp. 379–385, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. O. A. Olajide, J. M. Makinde, and D. T. Okpako, “Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae),” Inflammopharmacology, vol. 11, no. 3, pp. 293–298, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. Y. Sun, L. W. Oberley, and Y. Li, “A simple method for clinical assay of superoxide dismutase,” Clinical Chemistry, vol. 34, no. 3, pp. 497–500, 1988. View at Google Scholar · View at Scopus
  47. P. P. Bradley, D. A. Priebat, R. D. Christensen, and G. Rothstein, “Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker,” Journal of Investigative Dermatology, vol. 78, no. 3, pp. 206–209, 1982. View at Google Scholar · View at Scopus
  48. J. Sedlak and R. H. Lindsay, “Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent,” Analytical Biochemistry C, vol. 25, pp. 192–205, 1968. View at Google Scholar · View at Scopus
  49. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Google Scholar · View at Scopus
  50. A. Romero, E. Planas, R. Poveda, S. Sánchez, O. Pol, and M. M. Puig, “Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw,” European Journal of Pharmacology, vol. 511, no. 2-3, pp. 207–217, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. Zhang, A. Shaffer, J. Portanova, K. Seibert, and P. C. Isakson, “Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production,” Journal of Pharmacology and Experimental Therapeutics, vol. 283, no. 3, pp. 1069–1075, 1997. View at Google Scholar · View at Scopus
  52. A. Burke, E. M. Smyth, and G. A. FitzGerald, “Analgesic-antipyretic agents; pharmacotherapy of gout,” in Goodman & Gilman's the Pharmacological Basis of Therapeutics, L. L. Brunton, J. S. Lazo, and K. L. Parker, Eds., pp. 671–717, McGraw-Hill, New York, NY, USA, 2005. View at Google Scholar
  53. B. J. Undem, “Pharmacotherapy of asthma,” in Goodman & Gilman's the Pharmacological Basis of Therapeutics, L. L. Brunton, J. S. Lazo, and K. L. Parker, Eds., pp. 617–637, McGraw-Hill, New York, NY, USA, 2005. View at Google Scholar
  54. B. N. Vajja, S. Juluri, M. Kumari, L. Kole, R. Chakrabarti, and V. D. Joshi, “Lipopolysaccharide-induced paw edema model for detection of cytokine modulating anti-inflammatory agents,” International Immunopharmacology, vol. 4, no. 7, pp. 901–909, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. V. P. Nacife, N. Soeiro Mde, R. N. Gomes, H. D'Avila, H. C. Castro-Faria Neto, and N. Meirelles Mde, “Morphological and biochemical characterization of macrophages activated by carrageenan and lipopolysaccharide in vivo,” Cell Structure and Function, vol. 29, no. 2, pp. 27–34, 2004. View at Publisher · View at Google Scholar · View at Scopus
  56. H. C. Wulf and S. Ullman, “Discoid and subacute lupus erythematosus treated with 0.5% R-salbutamol cream,” Archives of Dermatology, vol. 143, no. 12, pp. 1589–1590, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. M. C. Oliveira, A. Pelegrini-da-Silva, C. A. Parada, and C. H. Tambeli, “5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue,” Neuroscience, vol. 145, no. 2, pp. 708–714, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. M. Barrot, I. Yalcin, N. Choucair-Jaafar, M. Benbouzid, and M. J. Freund-Mercier, “From antidepressant drugs to beta-mimetics: preclinical insights on potential new treatments for neuropathic pain,” Recent Patents on CNS Drug Discovery, vol. 4, no. 3, pp. 182–189, 2009. View at Publisher · View at Google Scholar · View at Scopus
  59. I. Kager, S. A. Mousa, J. Sieper, C. Stein, W. Pipam, and R. Likar, “Blockade of intra-articular adrenergic receptors increases analgesic demands for pain relief after knee surgery,” Rheumatology International, vol. 31, no. 10, pp. 1299–1306, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. K. Saha, N. H. Lajis, D. A. Israf et al., “Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants,” Journal of Ethnopharmacology, vol. 92, no. 2-3, pp. 263–267, 2004. View at Publisher · View at Google Scholar · View at Scopus
  61. M. Valko, C. J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur, “Free radicals, metals and antioxidants in oxidative stress-induced cancer,” Chemico-Biological Interactions, vol. 160, no. 1, pp. 1–40, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. G. A. Fitzgerald and C. Patrono, “The coxibs, selective inhibitors of cyclooxygenase-2,” The New England Journal of Medicine, vol. 345, pp. 433–442, 2001. View at Google Scholar · View at Scopus
  63. J. Emerit, M. Edeas, and F. Bricaire, “Neurodegenerative diseases and oxidative stress,” Biomedicine and Pharmacotherapy, vol. 58, no. 1, pp. 39–46, 2004. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Cadirci, A. Oral, F. Odabasoglu et al., “Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 381, no. 5, pp. 455–466, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. Z. Halici, M. Karaca, O. N. Keles et al., “Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation,” Fertility and Sterility, vol. 90, no. 6, pp. 2408–2415, 2008. View at Publisher · View at Google Scholar · View at Scopus
  66. X. F. Figueroa, I. Poblete, R. Fernandez, C. Pedemonte, V. Cortes, and J. P. Huidobro-Toro, “NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors,” American Journal of Physiology, vol. 297, no. 1, pp. H134–H143, 2009. View at Google Scholar
  67. R. M. Priest, D. Hucks, and J. P. Ward, “Potentiation of cyclic AMP-mediated vasorelaxation by phenylephrine in pulmonary arteries of the rat,” British Journal of Pharmacology, vol. 127, no. 1, pp. 291–299, 1999. View at Publisher · View at Google Scholar · View at Scopus
  68. R. M. Priest, D. Hucks, and J. P. T. Ward, “Noradrenaline, β-adrenoceptor mediated vasorelaxation and nitric oxide in large and small pulmonary arteries of the rat,” British Journal of Pharmacology, vol. 122, no. 7, pp. 1375–1384, 1997. View at Google Scholar · View at Scopus
  69. H. Y. Chang, “Role of nitric oxide in vasodilator response induced by salbutamol in rat diaphragmatic microcirculation,” American Journal of Physiology, vol. 272, no. 5, pp. H2173–H2179, 1997. View at Google Scholar · View at Scopus
  70. E. Cadirci, H. Suleyman, H. Aksoy et al., “Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats,” Chemico-Biological Interactions, vol. 170, no. 1, pp. 40–48, 2007. View at Publisher · View at Google Scholar · View at Scopus
  71. T. S. Saleh, J. B. Calixto, and Y. S. Medeiros, “Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan,” Peptides, vol. 20, no. 8, pp. 949–956, 1999. View at Publisher · View at Google Scholar · View at Scopus
  72. F. Odabasoglu, Z. Halici, H. Aygun et al., “alpha-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations,” British Journal of Nutrition, vol. 105, no. 1, pp. 31–43, 2011. View at Google Scholar
  73. C. S. Lee, Y. Y. Jang, J. S. Song, J. H. Song, and E. S. Han, “Ambroxol inhibits peroxynitrite-induced damage of alpha1-antiproteinase and free radical production in activated phagocytic cells,” Pharmacology & Toxicology, vol. 91, no. 3, pp. 140–149, 2002. View at Google Scholar
  74. I. M. Paino, V. F. Ximenes, L. M. da Fonseca, M. P. Kanegae, N. M. Khalil, and I. L. Brunetti, “Effect of therapeutic plasma concentrations of non-steroidal anti-inflammatory drugs on the production of reactive oxygen species by activated rat neutrophils,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 4, pp. 543–551, 2005. View at Google Scholar · View at Scopus
  75. Z. Halici, G. O. Dengiz, F. Odabasoglu, H. Suleyman, E. Cadirci, and M. Halici, “Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema,” European Journal of Pharmacology, vol. 566, no. 1–3, pp. 215–221, 2007. View at Publisher · View at Google Scholar · View at Scopus
  76. F. Odabasoglu, H. Aygun, Z. Halici et al., “Effect of alpha-lipoic acid on myeloperoxidase activity and lipid peroxidation level in carrageenan-injected rats,” The FEBS Journal, vol. 274, pp. 269–269, 2007. View at Google Scholar
  77. J. J. García, R. J. Reiter, J. M. Guerrero et al., “Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation,” FEBS Letters, vol. 408, no. 3, pp. 297–300, 1997. View at Publisher · View at Google Scholar · View at Scopus
  78. S. Tanas, F. Odabasoglu, Z. Halici et al., “Evaluation of anti-inflammatory and antioxidant activities of peltigera rufescens lichen species in acute and chronic inflammation models,” Journal of Natural Medicines, vol. 64, no. 1, pp. 42–49, 2010. View at Publisher · View at Google Scholar · View at Scopus
  79. A. Meister and M. E. Anderson, “Glutathione,” Annual Review of Biochemistry, vol. 52, pp. 711–760, 1983. View at Google Scholar · View at Scopus
  80. J. M. McCord, “Superoxide production and human disease,” in Molecular Basis of Oxidative Damage by Leukocytes, A. Jesaitis and E. Dratz, Eds., pp. 225–239, CRC, Boca Raton, Fla, USA, 1992. View at Google Scholar