Anti-Inflammatory and Antinociceptive Effects of Salbutamol on Acute and Chronic Models of Inflammation in Rats: Involvement of an Antioxidant Mechanism

Table 2

Effects of salbutamol and indomethacin on carrageenan-induced inflammatory paw nociception in rats.

Drugs	Decrease in nociceptive threshold (g)			Analgesic effect (%)
	1st h	2nd h	3rd h	1st h	2nd h	3rd h
SAL-1	18.2 ± 1.3*	25.7 ± 2.4*	30.2 ± 3.3*	57	44.2	36.9
SAL-2	16.7 ± 2.7*	24.0 ± 4.8*	27.3 ± 4.1*	61.1	47.8	42.9
IND	12.2 ± 2.2*	20.7 ± 4.4*	19.8 ± 5.1*	71.6	55	58.5
Control	42.8 ± 5.4	46.0 ± 2.5	47.8 ± 2.7	—	—	—

SAL-1: salbutamol 1 mg/kg; SAL-2: salbutamol 2 mg/kg; IND: indomethacin 25 mg/kg. *Significant at 𝑃<0.05 when compared to control. (All groups received an intraplantar injection of 0.1 mL, 1% carrageenan.)