Does Inflammation Determine Whether Obesity Is Metabolically Healthy or Unhealthy? The Aging Perspective

<table>Conversion of naïve LDL to oxidized LDL and formation of foam cells from monocytes: implication of aging and obesity in sustaining/worsening inflammation. A typical example of how chronic condition can participate in the development of diseases. In this case, atherosclerotic plaque formation is increased by parallel proinflammatory signals derived from obesity and/or inflammaging. LDL: low-density lipoprotein; ROS: reactive oxygen species; CMV: cytomegalovirus; RANTES: regulated and normal T cell expressed and secreted.</table>

Mediators of Inflammation

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Figure 3: Does Inflammation Determine Whether Obesity Is Metabolically Healthy or Unhealthy? The Aging Perspective 