Low Dose Theophylline Showed an Inhibitory Effect on the Production of IL-6 and IL-8 in Primary Lung Fibroblast from Patients with COPD
Increased mRNA expression and protein production of interleukin-6 (IL-6) in lung fibroblasts from COPD patients. (a) Real-time RT-PCR was adopted to evaluate the transcription levels of IL-6, and the relative expression was calculated based on the expression of GAPDH. ***, when compared to control group. (b) The relationship of IL-6 mRNA expression and FEV1. (c) The protein level of IL-6. ELISA was used to measure the concentration of IL-6 in the cell-free supernatants. *, when compared to control group. (d) The relationship of IL-6 secretion and FEV1.
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