Mediators of Inflammation / 2012 / Article / Fig 4

Research Article

Low Dose Theophylline Showed an Inhibitory Effect on the Production of IL-6 and IL-8 in Primary Lung Fibroblast from Patients with COPD

Figure 4

The effect of theophylline on the lipopolysaccharide-induced cytokine production in primary human lung fibroblasts. Data were obtained from 8 independent cell lines. The cells were cultured for 48 h at the absence or presence of 1 μg/mL LPS, and the effect of theophylline at the concentration of 5 μg/mL was analyzed. The production of IL-6 (a) and IL-8 (b) was quantitated by ELISA. The results were expressed as m e a n ± S D in picograms per milliliter. 𝑃 < 0 . 0 5 , when statistics were performed among −LPS/−Theo, +LPS/−Theo, and +LPS/+Theo. * 𝑃 < 0 . 0 5 , ** 𝑃 < 0 . 0 1 , and *** 𝑃 < 0 . 0 0 1 , when results between two different treatments were compared. LPS: lipopolysaccharide; IL: interleukin; Theo: theophylline.
492901.fig.004a
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492901.fig.004b
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