Review Article
PGD Synthase and PGD2 in Immune Resposne
Table 1
Summary of PGDS and PGD2 effects in models of inflammation.
| | Model | Reference |
| H-PGDS | | | Proinflammatory | Allergic airway inflammation (mouse model) | [18] | Anti-inflammatory | Delayed type hypersensitivity (mouse model) | [24, 25] |
| L-PGDS | | | Pro-inflammatory | Allergic airway inflammation (mouse model) | [40] | Chronic allergic dermatitis (mouse model) | [41] | Human ulcerative colitis | [42] | Diabetic nephropathy (mouse Model) | [43–45] | Anti-inflammatory | LPS-induced lung inflammation (mouse model) | [33] | Immunoprotective | P. aeruginosa lung inflammation (mouse model) | [33] |
| PGD2 | | | Pro-inflammatory | Asthma and allergic airway inflammation (mouse model) | [40, 47] | Neuroinflammation/Krabbe’s disease (mouse Model) | [48] | Skin inflammation (mouse model) | [49] | Anti-inflammatory | Mouse model of pleuritis | [3] | Mouse model of colitis | [50] | Immunosuppressive | Viral infection (mouse Model) | [51] |
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