Table 1: Summary of PGDS and PGD2 effects in models of inflammation.

ModelReference

H-PGDS
ProinflammatoryAllergic airway inflammation
(mouse model)
[18]
Anti-inflammatoryDelayed type hypersensitivity
(mouse model)
[24, 25]

L-PGDS
Pro-inflammatoryAllergic airway inflammation
(mouse model)
[40]
Chronic allergic dermatitis
(mouse model)
[41]
Human ulcerative colitis[42]
Diabetic nephropathy
(mouse Model)
[4345]
Anti-inflammatoryLPS-induced lung inflammation
(mouse model)
[33]
ImmunoprotectiveP. aeruginosa lung inflammation
(mouse model)
[33]

PGD2
Pro-inflammatoryAsthma and allergic airway inflammation
(mouse model)
[40, 47]
Neuroinflammation/Krabbe’s disease
(mouse Model)
[48]
Skin inflammation
(mouse model)
[49]
Anti-inflammatoryMouse model of pleuritis[3]
Mouse model of colitis[50]
ImmunosuppressiveViral infection
(mouse Model)
[51]