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Mediators of Inflammation
Volume 2012 (2012), Article ID 564027, 11 pages
http://dx.doi.org/10.1155/2012/564027
Research Article

Mobilization of CD34+CXCR4+ Stem/Progenitor Cells and the Parameters of Left Ventricular Function and Remodeling in 1-Year Follow-up of Patients with Acute Myocardial Infarction

1Third Division of Cardiology, Medical University of Silesia, 45-47 Ziołowa Street, 40-635 Katowice, Poland
2Institute of Cardiology Jagiellonian University, John Paul II Hospital, Pradnicka 80, 31-202 Krakow, Poland
3Department of Transplantation, Jagiellonian University, Wielicka 265, 30-663 Krakow, Poland
4American Heart of Poland, Sanatoryjna 1, 43-450 Ustroń, Poland
5Division of Vascular Surgery, Medical University of Silesia, 45-47 Ziołowa Street, 40-635 Katowice, Poland
6Stem Cell Institute, University of Louisville, 2301 South 3rd Street, Louisville, KY 40208, USA

Received 27 November 2011; Revised 6 January 2012; Accepted 10 January 2012

Academic Editor: Thomas Schindler

Copyright © 2012 Rafał Wyderka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mobilization of stem cells in acute MI might signify the reparatory response. Aim of the Study. Prospective evaluation of correlation between CD34+CXCR4+ cell mobilization and improvement of LVEF and remodeling in patients with acute MI in 1-year followup. Methods. 50 patients with MI, 28 with stable angina (SAP), and 20 individuals with no CAD (CTRL). CD34+CXCR4+ cells, SDF-1, G-CSF, troponin I (TnI) and NT-proBNP were measured on admission and 1 year after MI. Echocardiography and ergospirometry were carried out after 1 year. Results. Number of CD34+CXCR4+ cells in acute MI was significantly higher in comparison with SAP and CTRL, but lower in patients with decreased LVEF ≤40%. In patients who had significant LVEF increase ≥5% in 1 year FU the number of cells in acute MI was significantly higher versus patients with no LVEF improvement. Number of cells was positively correlated ( 𝑟 = 0 , 4 1 , 𝑃 = 0 , 0 3 1 ) with absolute LVEF change and inversely with absolute change of ESD and EDD in 1-year FU. Mobilization of CD34+CXCR4+ cells in acute MI was negatively correlated with maximum TnI and NT-proBNP levels. Conclusion. Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year.