Role of Leukotrienes on Protozoan and Helminth Infections
Figure 1
Modulation of innate and adaptive immune responses by LTs during the protozoan infections. Protective immunity against protozoans is mainly mediated by Th1 responses characterized by the production of inflammatory cytokines, such as IFN-, which activate macrophages to control of parasite replication. Macrophages are a source of LTs. (A) LTB4 induces cytotoxicity in parasites. (B) LTB4 and LTD4 favored parasite killing by macrophages. (C) LTB4 induces chemotaxis of CD4+ T cells. (D) LTB4 induces the production of Th1 cytokines, such as IFN-.
