Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2012, Article ID 610371, 6 pages
http://dx.doi.org/10.1155/2012/610371
Research Article

Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor

1Microbiology, Immunology, and Parasitology Department, Federal University of São Paulo, 04023-900 São Paulo, SP, Brazil
2Pathology Division, Adolfo Lutz Institute, 01246-000 São Paulo, Brazil
3Immunology Department, University of São Paulo, 05508-900 São Paulo, SP, Brazil
4Pharmacology Department, Federal University of São Paulo, 04023-032 São Paulo, SP, Brazil

Received 1 October 2011; Accepted 1 February 2012

Academic Editor: M. Sanchez Crespo

Copyright © 2012 André Luis Lacerda Bachi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Liotta and E. C. Kohn, “The microenvironment of the tumour-host interface,” Nature, vol. 411, no. 6835, pp. 375–379, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Allavena, A. Sica, G. Solinas, C. Porta, and A. Mantovani, “The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages,” Critical Reviews in Oncology/Hematology, vol. 66, no. 1, pp. 1–9, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani, “Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability,” Carcinogenesis, vol. 30, no. 7, pp. 1073–1081, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. M. Prescott, G. A. Zimmerman, D. M. Stafforini, and T. M. McIntyre, “Platelet-activating factor and related lipid mediators,” Annual Review of Biochemistry, vol. 69, pp. 419–445, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. I. Honda, S. Ishii, and T. Shimizu, “Platelet-activating factor receptor,” Journal of Biochemistry, vol. 131, no. 6, pp. 773–779, 2002. View at Google Scholar · View at Scopus
  6. S. I. de Oliveira, P. D. Fernandes, J. G. P. Amarante Mendes, and S. Jancar, “Phagocytosis of apoptotic and necrotic thymocytes is inhibited by PAF-receptor antagonists and affects LPS-induced COX-2 expression in murine macrophages,” Prostaglandins and Other Lipid Mediators, vol. 80, no. 1-2, pp. 62–73, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. V. A. Fadok, D. L. Bratton, and P. M. Henson, “Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences,” Journal of Clinical Investigation, vol. 108, no. 7, pp. 957–962, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. S. I. de Oliveira, L. N. S. Andrade, A. C. Onuchic et al., “Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy,” BMC Cancer, vol. 10, p. 200, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Correa, J. Machado, C. R. W. Carneiro et al., “Transient inflammatory response induced by apoptotic cells is an important mediator of melanoma cell engraftment and growth,” International Journal of Cancer, vol. 114, no. 3, pp. 356–363, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. S. M. Oba-Shinjo, M. Correa, T. I. Ricca et al., “Melanocyte transformation associated with substrate adhesion impediment,” Neoplasia, vol. 8, no. 3, pp. 231–241, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. A. L. L. Bachi, F. J. K. Kim, S. Nonogaki et al., “Leukotriene B4 creates a favorable microenvironment for murine melanoma growth,” Molecular Cancer Research, vol. 7, no. 9, pp. 1417–1424, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Hammond-McKibben, P. Lake, J. Zhang, N. Tart-Risher, R. Hugo, and M. Weetall, “A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor,” Journal of Pharmacology and Experimental Therapeutics, vol. 297, no. 3, pp. 1144–1151, 2001. View at Google Scholar · View at Scopus
  13. S. Fernandez-Gallardo, M. Del Pilar Ortega, J. G. Priego, M. Fau De Casa-Juana, C. Sunkel, and M. Sanchez Crespo, “Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonists: in vivo studies,” Journal of Pharmacology and Experimental Therapeutics, vol. 255, no. 1, pp. 34–39, 1990. View at Google Scholar · View at Scopus
  14. F. J. O. Rios, M. Gidlund, and S. Jancar, “Pivotal role for platelet-activating factor receptor in CD36 expression and oxLDL uptake by human monocytes/macrophages,” Cellular Physiology and Biochemistry, vol. 27, no. 3-4, pp. 363–372, 2011. View at Publisher · View at Google Scholar
  15. F. J. Rios and S. Jancar, “Co-stimulation of PAFR and CD36 is required for oxLDL-induced human macrophages activation,” In press.
  16. K. S. Siveen and G. Kuttan, “Role of macrophages in tumour progression,” Immunology Letters, vol. 123, no. 2, pp. 97–102, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Mantovani and M. A. Pierotti, “Cancer and inflammation: a complex relationship,” Cancer Letters, vol. 267, no. 2, pp. 180–181, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Somasundaram and D. Herlyn, “Chemokines and the microenvironment in neuroectodermal tumor-host interaction,” Seminars in Cancer Biology, vol. 19, no. 2, pp. 92–96, 2009. View at Publisher · View at Google Scholar · View at Scopus