Peripheral Leukocytapheresis Attenuates Acute Lung Injury Induced by Lipopolysaccharide In Vivo
Figure 2
The effect of LPS and LCAP on WBC and PMN counts and NE level in periphery. The numbers of WBCs and PMNs collected from the right femoral artery at indicated time periods after LPS injection were detected using the Digicell 500 cell counter and enumerated with Giemsa-Wright Stain. The animals in the LPS group underwent only LPS injection at the zero time point. Except for LPS administration, the animals in the sham-LCAP group underwent a sham-LCAP procedure (carried out by reinfusion of the end-products collected in a storage bag) at time point 16 h, for up to 4 h. and the animals in the LCAP group underwent both LPS injection and LCAP at corresponding time points. (a) WBC counts following the LPS injection and LCAP (/sham-LCAP). (b) PMN counts following LPS injection and LCAP (/sham-LCAP). (c) The level of NE following LPS injection and LCAP (/sham-LCAP). *indicates significant difference among the LCAP, LPS, and sham-LCAP groups at the indicated time (*; **). #indicates significant difference between the LCAP and LPS groups at the indicated time ().
