Interleukin-1β Accelerates the Onset of Stroke in Stroke-Prone Spontaneously Hypertensive Rats
IL-1β level in plasma and IL-1β signal-related gene expression in CVECs from each strain. Plasma and CVECs were harvested from WKY, SHR, and SHRSP (male, 4 weeks of age). Total RNA was extracted for quantitative real time PCR. (a) IL-1β level in plasma and (b) IL-1β signal-related gene expression, such as (A) IL-1β, (B) IL-1RI, (C) IL-1RII, (D) caspase-1, (E) MCP-1, and (F) ICAM-1 in CVECs were measured as described in the methods section. Bars show SD, *** versus WKY, ††† versus SHR. in each strain. N.D.: not detectable.