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Mediators of Inflammation
Volume 2012, Article ID 720976, 8 pages
http://dx.doi.org/10.1155/2012/720976
Clinical Study

IL-8, IL-10, TGF-, and GCSF Levels Were Increased in Severe Persistent Allergic Asthma Patients with the Anti-IgE Treatment

1Allergy and Clinical Immunology Unit, Department of Internal Medicine, Antalya Training and Research Hospital, 07070 Antalya, Turkey
2Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, 58185 Linköping, Sweden
3Department of Medical Genetics, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey
4Division of Cellular and Molecular Biology, Toronto Hospital, University Health Network, Toronto, ON, Canada M5G 2C4

Received 3 August 2012; Revised 18 October 2012; Accepted 22 November 2012

Academic Editor: Gustavo Duarte Pimentel

Copyright © 2012 Arzu D. Yalcin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Allergic asthma is showed an increase in Th2-cytokine and IgE levels and an accumulation activation of Th2 cells, eosinophils and mast cells. However, recent studies focused on cell-based mechanisms for the pathogenesis of allergic asthma. Objectives. In this study, we compare the anti-IgE treatment modality in the dynamics of immune system cytokine levels in severe persistent asthma (SPA) patients who had no other any allergic disease, newly diagnosed allergic asthma patients and healthy volunteers. Study Design. The study population consisted of 14 SPA patients, 14 newly diagnosed allergic asthma patients and 14 healthy volunteers included as controls. Cytokine levels were measured. Total and specific IgE levels of anti-IgE monoclonal antibody treated patients, serum high-sensitivity C-reactive protein (hsCRP) levels, FEV1/FVC rates and asthma control test (ACT) were measured for the clinical follow-up. Results. We observed that SPA patients presented increasing levels of IL-8, IL-10, TGF-β and GCSF during the anti-IgE treatment in period of sampling times at 4 months and 18 months. However this increase was not correlated neither with serum hsCRP levels nor FEV1/FVC rates. Conclusions. Our study gives a different perspective for the SPA and anti-IgE immunotherapy efficacy at the cell cytokine-linked step.