Serum IL-18 Is Closely Associated with Renal Tubulointerstitial Injury and Predicts Renal Prognosis in IgA Nephropathy

Table 1

Demographic, clinical, and histological data in IgAN patients at baseline.

Parameter	Data
Male/female	37/39
Age (year)	38.85 ± 10.95
Smoking history (%)	13 (17.11)
SBP (mmHg)	124.42 ± 19.18
DBP (mmHg)	80.58 ± 12.40
Hemoglobin (g/dL)	124.16 ± 18.74
Proteinuria (g/24 h)	2.61 (1.43~4.08)
sAlb (g/L)	36.12 ± 6.26
Scr (μmol/L)	95.90 (78.00~118.40)
eGFR (mL/min/1.73 m^2)	75.83 ± 4.41
sIgA (mmol/L)	3.09 ± 1.15
Hs-CRP (mg/L)	4.56 ± 0.92
Cholesterol (mmol/L)	5.87 ± 1.24
Triglyceride (mmol/L)	2.68 ± 0.61
sIL-18 (pg/mL)	360.26 ± 25.23
Lee’s grading system
Grade III	17 (22.36%)
Grade IV	39 (51.31%)
Grade V	20 (26.32%)
GSS	0.24 (0.09−0.50)
TID	4.00 (2.00−6.00)

Data are mean ± SD or median interquartile range, and comparisons between groups were made by the Student’s t-test or 𝜒2 test as appropriate. SBP, systolic blood pressure; DBP, diastolic blood pressure; SAlb, serum albumin; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; sIgA, serum immunoglobulin A; Hs-CRP, high-sensitivity C-reactive protein; sIL-18, serum interleukin-18; GSS, global and segmental sclerosis; TID, tubulointerstitial damage.