Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst

Figure 3

SOD3 downregulated arthritis in the absence of functional NOX2 complex. Arthritis severity was significantly reduced in Ade-SOD3-treated paws of mice lacking functional oxidative burst when compared to the control vector-treated paws (a). Shown is pooled data from two independent experiments (Ade-SOD3 𝑛=22, Ade-lacZ 𝑛=23). The difference in arthritis score in the treated paw between the PBS-treated control mice (𝑛=10) and Ade-SOD3-treated mice was smaller than the difference between PBS-treated and Ade-LacZ-treated mice at days 24 and 25 (b).

(a)

(b)