Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2012 (2012), Article ID 730923, 6 pages
http://dx.doi.org/10.1155/2012/730923
Clinical Study

Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection

1Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
2Heart Center, Peking University People’s Hospital, Beijing 100044, China

Received 17 January 2012; Accepted 21 February 2012

Academic Editor: Sunil Kumar Manna

Copyright Β© 2012 Wenliang Che et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Prior study showed HCV-infected patients have increased serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and a possible left ventricular diastolic dysfunction. The objectives of the present paper were to investigate the characteristics of hs-CRP and its correlation with clinical profiles including NT-proBNP and echocardiographic variables in HCV-infected patients. Methods and Results. A total of 106 HCV-infected patients and 106 control healthy individuals were enrolled. The level of serum hs-CRP (median 1.023 mg/L, range 0.03~5.379 mg/L) was significantly lower in all 106 patients than that in controls (median 3.147 mg/L, range 0.08~7.36 mg/L, 𝑃 = 0 . 0 1 2 ). Although hs-CRP did not correlate significantly with NT-proBNP when all patients and controls were included ( π‘Ÿ = 0 . 1 6 9 , 𝑃 = 0 . 1 2 1 ), simple regression analysis demonstrated a statistically significant linear correlation between hs-CRP and NT-proBNP in HCV-infected patients group ( π‘Ÿ = 0 . 3 9 2 , 𝑃 = 0 . 0 1 7 ). Independent correlates of hs-CRP levels ( 𝑅 2 = 0 . 1 3 ) were older age ( 𝛽 ξ…ž = 0 . 0 3 1 , 𝑃 = 0 . 0 2 5 ) and NT proBNP ( 𝛽 ξ…ž = 0 . 0 2 4 , 𝑃 = 0 . 0 1 7 ). Conclusions. Although the level of serum hs-CRP decreased significantly, there was a significant association between hs-CRP and NT-proBNP in HCV-infected patients.