CXCL1-Triggered Interaction of LFA1 and ICAM1 Control Glucose-Induced Leukocyte Recruitment during Inflammation In Vivo

Table 2

Hemodynamic and microvascular parameters of cremaster muscle venules before and after stimulation with glucose in the TNFα model. Vessel diameter, centerline velocity, and wall shear rate are displayed before and after the intravenous administration of 0,5 g/kg glucose and compared to the application of the equivalent volume of normal saline. Experiments are presented as mean ± SEM; n.s.: not significant, stating no differences of hemodynamic parameters during the time course after glucose/saline injection.

	Mice	Venules	Diameter	Centerline velocity	Wall shear rate	Systemic leukocyte counts
	𝑁	𝑛	(𝜇m)	(𝜇m/s)	(s^−1)	(/𝜇L)
Injection of saline
Pre-saline	4	9	28 ± 1	1900 ± 100	1800 ± 200	4200 ± 200
5′ after saline	4	9	28 ± 1	1900 ± 100	1800 ± 200	4300 ± 200
15′ after saline	4	9	28 ± 1	1900 ± 100	1800 ± 100	4300 ± 200
				n.s.	n.s.	n.s.
Injection of glucose
Pre-glucose	5	17	27 ± 1	1900 ± 100	1800 ± 100	3700 ± 200
5′ after glucose	5	17	27 ± 1	2200 ± 100	1900 ± 100	3700 ± 200
15′ after glucose	5	17	27 ± 1	2000 ± 100	1800 ± 100	3900 ± 200
				n.s.	n.s.	n.s.