CXCR2 in Acute Lung Injury

Table 2

Pharmacological approaches on CXCR2 in animals.

Intervention	Model	Results	Reference
Blocking CXCR2 by a self-made antagonist*	Lung transplant ischemia-reperfusion injury in rats	(i) Marked reduction of neutrophils into the lung; (ii) Attenuated graft injury	[18]
Blocking CXCR2 by a self-made antagonist*	Ventilator-induced ALI in mice	(i) Reduced PMN sequestration and ALI	[17]
Reparixin	LPS-/acid-induced ALI in mice	(i) Modulation of PMN trafficking; (ii) Reduced vascular permeability; (iii) Improved gas exchange	[34]
Reparixin	Reperfusion injury in rats and human/rodent PMNs	(i) Effective inhibitor of PMN recruitment; (ii) Attenuated reperfusion injury	[35]
Reparixin	Cerebral ischemia in rats	(i) Anti-inflammatory and neuroprotective effects; (ii) Inhibition of PMN infiltration; (iii) Reduced tissue damage	[36]
Reparixin	Intestinal ischemia and reperfusion injury in rats	(i) Reduced neutrophil influx; (ii) Reduced microvascular permeability in lungs and intestines; (iii) Reduced TNFα; (iv) Reduced lethality	[37]
DF2162	Bleomycin-induced pulmonary inflammation and fibrosis in mice	(i) Improvement of lung pathology; (ii) Reduced collagen deposition; (iii) Reduced airway PMN migration; (iv) Increased PMN in lung parenchyma	[26]
SCH-N	Cigarette smoke-induced lung inflammation in mice	(i) Reduced PMNs in BAL; (ii) Reduced perivascular inflammation; (iii) Reduced tissue PMNs	[38]
DF 2156A	Human leukocytes, human umbilical vein cells, ischemia/reperfusion injury in rats	(i) Decreased monocyte and PMN infiltration; (ii) Reduced TNFα; (iii) Attenuated proliferation, migration and capillary-like organization of human umbilical vein endothelial cells	[39]
DF2156A	Ischemia/reperfusion injury in rats	(i) Decrease of PMN infiltration; (ii) Reduced infarct size; (iii) Improved neurological function	[40]
K11R/G31P	Aspiration pneumonia in pigs	(i) Attenuated neutrophil response; (ii) Reduced pathology; (iii) Still efficient pulmonary bacterial clearance	[41]
K11R/G31P	LPS-induced lung inflammation in pigs	(i) Decreased PMN migration into the lung; (ii) Reduced TNFα andl IL-1 levels in the BAL	[42]
K11R/G31P	Radiation-induced lung injury in mice	(i) Reduced alveolitis but not fibrosis	[28]
Sch527123*	Intranasal/intratracheal LPS-administration in mice, and rats, repeated bronchoscopy and lavage in cynomolgus monkey	(i) Suppressed pulmonary neutrophilia; (ii) Reduced goblet cell hyperplasia	[43]
Simvastatin	Streptococcal-induced ALI in mice	(i) Reduced infiltration of neutrophils and edema in the lung	[44]

*Selective for CXCR2; the other pharmacologic agents also inhibit CXCR1.