CXCR2 in Acute Lung Injury

Table 3

Pharmacological approaches on CXCR2 in humans.

Intervention	Model	Results	Reference
DF 2156A	Human leukocytes, human umbilical vein cells, ischemia/reperfusion injury in rats	(i) Decreased monocyte and PMN infiltration; (ii) Reduced TNFα; (iii) Attenuated proliferation,; migration and capillary-like organization of human umbilical vein endothelial cells	[39]
Sch527123	Human neutrophils	(i) Inhibited neutrophil chemotaxis; (ii) Inhibited myeloperoxidase release	[45]
Sch527123	Ozone-induced neutrophil recruitment in humans	(i) Lower sputum neutrophil count	[46]
SB-65933*	Ozone-induced airway inflammation in humans	(i) Lower neutrophil activation and recruitment	[47]

*Selective for CXCR2, the other pharmacologic agents also inhibit CXCR1.