Biphasic Activation of Nuclear Factor-Kappa B in Experimental Models of Subarachnoid Hemorrhage In Vivo and In Vitro

Figure 2

NF-κB activity in Hb-incubated neurons was determined by EMSA in control, 1 h, 3 h, 6 h, 12 h, 24 h, and 48 h groups (lanes 1, 2, 3, 4, 5, 6, and 7 in (a) resp.; 𝑛=6 per group). NF-κB activity in cultured neurons was significantly increased after incubated with Hb (𝑃<0.05). The NF-κB activity showed the double peaks in 1 h and 12 h groups, *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 versus control group. Bars represent the mean ± SEM.

(a)

(b)