Pegylated Arginine Deiminase Downregulates Colitis in Murine Models
Effects of ADI-PEG therapy on the clinical disease index in DSS-induced acute colitis. ADI-PEG was administered i.p on day 0 and day 5. Clinical disease index was determined by parameters as means for extent of weight loss, presence of diarrhea, rectal bleeding, prolapse, and anemia (/group). ADI-PEG markedly decreased the clinical disease index in WT and IL-10-deficient colitic mice.