The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome

Table 3

Correlation coefficients between circulating Th17, Treg, or ratio and BMI, PSG parameters, and inflammatory cytokines in OSAS patients (𝑛=44).

Parameters	Th17		Treg		Th17/Treg
	r	P	r	P	r	P
BMI	0.124	NS	0.140	NS	0.260	NS
AHI	0.284	NS	−0.290	NS	0.321	0.029
Nadir SaO2 (%)	0.189	NS	−0.238	NS	0.194	NS
SaO2 < 90% (%TST)	0.207	NS	−0.274	NS	0.262	NS
ESS scores	0.175	NS	−0.266	NS	0.178	NS
RORγt/GADPH mRNA	0.483	0.001	−0.114	NS	0.076	NS
Foxp3/GADPH mRNA	−0.234	NS	0.435	0.003	−0.053	NS
IL-10 (pg/mL)	0.089	NS	0.120	NS	0.095	NS
TGF-β 1 (pg/mL)	−0.291	NS	0.427	0.004	−0.211	NS
IL-17 (pg/mL)	0.525	<0.001	−0.224	NS	0.288	NS
IL-6 (pg/mL)	0.068	NS	0.106	NS	0.183	NS
hsCRP (pg/mL)	0.372	0.013	−0.433	0.003	0.475	0.001

Definition of abbreviations:
AHI: apnoea hypopnoea index; BMI: body mass index; hsCRP: high-sensitivity C-reactive protein; ESS: Epworth sleepiness scale; nadir: lowest oxygen saturation recorded; OSAS: obstructive sleep apnoea syndrome; TST: total sleep time.