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Mediators of Inflammation
Volume 2012, Article ID 819636, 7 pages
http://dx.doi.org/10.1155/2012/819636
Research Article

Serum IL-33 Levels Are Associated with Liver Damage in Patients with Chronic Hepatitis C

1Department of Central Laboratory, The Second Part of First Hospital, Jilin University, Changchun 130032, China
2Department of Hepatology, First Hospital, Jilin University, Changchun 130032, China

Received 23 August 2011; Revised 18 October 2011; Accepted 19 October 2011

Academic Editor: Giamila Fantuzzi

Copyright © 2012 Juan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and 20 healthy controls (HC), were analyzed by ELISA. The concentrations of serum IL-2, IFN-γ, TNF-α, IL-4, IL-6, and IL-10, HCV loads, ALT, AST, and HCV-Ab were measured. We found that the levels of serum IL-33 in CHC patients were significantly higher than those of SR-HCV and HC but decreased after treatment with interferon for 12 weeks. More importantly, the levels of serum IL-33 were correlated with the concentrations of ALT and AST in CHC patients. The levels of serum sST2, as a decoy receptor of IL-33, were significantly higher in CHC and SR-CHC patients than those in HC, and there was no correlation between the levels of serum sST2 and IL-33. The concentrations of serum IFN-γ and IL-6 in CHC patients were significantly lower than those of SR-HCV. These data suggest that IL-33 may be a pathogenic factor contributing to CHC-related liver injury.