Systemic Treatment of Vitreous Inflammation

Table 2

Uses of immunosuppressive agents in ophthalmologic conditions.

Drug	Diagnosis
Antimetabolites
Methotrexate	Chronic non-infectious uveitis, sarcoidosis, and non-infectious ocular inflammation
Azathioprine	Chronic uveitis, Behcet’s disease, choroidal neovascularization, OCP, retinal vasculitis, serpiginous choroiditis, and neuroretinitis
Mycophenolate mofetil	Chronic uveitis, non-infectious ocular inflammation, intermediate and posterior uveitis, refractory uveitis, and scleritis
Leflunomide	Sarcoidosis uveitis
Alkylating agents
Cyclophosphamide	Refractory uveitis, peripheral uveitis, Wegener, OCP, scleritis, Behçet’s disease, non-infectious ocular inflammation, and optic neuropathy (SLE)
Chlorambucil	Serpiginous choroiditis, severe chronic uveitis, uveitis, and Behçet’s disease
T-cell inhibitors/calcineurin inhibitors
Cyclosporine	Serpiginous choroidopathy, Behçet’s disease, endogenous uveitis, chronic idiopathic uveitis, scleritis, rheumatoid arthritis, and non-infectious uveitis
Tacrolimus	Refractory uveitis (limited experience)
Rapamycin	Refractory uveitis (limited experience)
Biologic agents
Etanercept	Juvenile idiopathic arthritis, non-infectious uveitis, and ocular inflammatory disease
Infliximab	Refractory uveitis, childhood uveitis, Behcet’s disease, and refractory uveitis
Adalimumab	Refractory uveitis, ankylosing spondylitis, and juvenile idiopathic arthritis
Daclizumab	Juvenile idiopathic arthritis, recalcitrant ocular inflammation, and birdshot retinochoroidopathy
Rituximab	Primary Sjogren syndrome, thyroid eye disease, and Wegener
Tocilizumab	Refractory uveitis (limited experience)
Other
Interferons	Behcet’s disease, non-infectious uveitis