Review Article

Innate Immune Cells in Liver Inflammation

Figure 3

Innate immune cell (neutrophils, NK cells and monocytes) recruitment to hepatic inflammation. Human liver receives dual blood supply from both portal vein and hepatic artery. During the inital event of hepatic inflammation, innate immune cells such as neutrophils, monocytes and NK cells are recruited to the liver. Liver resident dendritic cells sample the foreign antigen and carry to local draining portal lymph nodes where antigens are presented to the adaptive naive T cells. Following the antigen presentation, different types of antigen-specific T effectors cells leave the nodes and drain back to systemic circulation. These T effector cells recruit via hepatic sinusoid towards the site of injury or inflammation. Th17 cells which secrete IL-17 attract neutrophils and also link innate and adaptive immunity.
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