4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages
Figure 5
Schematic representation of the bidirectional signal transduction induced by 4-1BB/4-1BBL-mediated interaction between adipocytes and macrophages. The release of inflammatory cytokines (MCP-1, TNF-α, and IL-6) in response to the bidirectional signaling appears to participate in adipose inflammation.