The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages

Table 2

Naturally occurring compounds targeting TBK1.

Compound	Cells	Action target of TBK1	Reference
Resveratrol	Epithelial cells; RAW264.7 cells	Production of IL-6, TNF-𝛼, IFN-1, and iNOS	[13, 37]
Luteolin	RAW264.7 macrophage	Expression of TNF-𝛼, IL-6, IL-12, IP-10, IFN-β, CXCL9, and IL-27	[38]
Quercetin	RAW264.7 macrophage	Expression of IP-10, IFN-β	[38]
EGCG	RAW264.7 macrophage	TRIF-dependent signaling pathways	[38, 39]
Chrysin	RAW264.7 macrophage	Expression of IP-10, IFN-β	[38]
Eriodictyol	RAW264.7 macrophage	Expression of IP-10, IFN-β	[38]