Table 2: Naturally occurring compounds targeting TBK1.

CompoundCellsAction target of TBK1Reference

Resveratrol
Epithelial cells
RAW264.7 cells
Production of IL-6, TNF- , IFN-1, and iNOS[13, 37]
LuteolinRAW264.7 macrophageExpression of TNF- , IL-6, IL-12, IP-10, IFN-β, CXCL9, and IL-27[38]
QuercetinRAW264.7 macrophageExpression of IP-10, IFN-β[38]
EGCGRAW264.7 macrophageTRIF-dependent signaling pathways[38, 39]
ChrysinRAW264.7 macrophageExpression of IP-10, IFN-β[38]
EriodictyolRAW264.7 macrophageExpression of IP-10, IFN-β[38]