Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats
Effect of HFCR on liver and epididymal WAT morphology in high-fat diet induced obese rats. (a) H and E staining of liver from the three groups of animals (magnification X 40). The scale bar represents 250 μm. (b) representative H and E staining of adipose depots from the three groups of animals (magnification X 20). The scale bar represents 250 μm. CON: rats fed a control diet (10% kcal fat) ad libitum for the experimental periods, HF: rats fed a high-fat diet ad libitum for the experimental periods, and HFCR: 40% calorie-restricted rats fed a high-fat diet (45% kcal fat) for 8–10 weeks after being fed the high-fat diet ad libitum for 11–13 weeks.