Neisseria gonorrhoeae Induces a Tolerogenic Phenotype in Macrophages to Modulate Host Immunity
Figure 4
Hyporesponsive alloantigen T-cell responses induced by RAW cells infected with N. gonorrhoeae P9-17. Allogeneic H- splenocytes were cultured with RAW cells treated with gonococcus, medium and LPS. At day 5, CD4+ T-cell proliferation was determined by CFSE dilution analysis. Representative histogram plots are shown in the upper panel. Percentages of proliferation are indicated in the upper left quadrant. Bars represent mean SEM of 5 independent experiments performed in triplicate. ** indicates that P9-17 induces lower percentages of alloantigen proliferation than LPS and other treatments .
