Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice

Figure 3

Effect of the therapeutic treatment with ellagic acid on IL-6 (a), IL-1β (b), KC (c), and IL-10 (d) levels in BALF. Evans Blue dye extravasation into BALF was also determined 12 h after ALI (e) (see Materials and Methods). Mice received in the therapeutic scheme ellagic acid (10 mg/kg, p.o.), dexamethasone (1 mg/kg, s.c.), or vehicle (water, p.o.) after (2 h) the acid intratracheal instillation into the left lung (see Methods). The analyses of lung were carried out in the peak of inflammation (12 h). Results represent the mean ± SEM of two or more independent experiments with three mice per group per experiment. ^∗𝑃<0.05 compared with control group;  ^#𝑃<0.05 compared with HCl + vehicle group.

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