Table 3: Cytokine mRNA levels in patients with severe sepsis and controls. Values denote copy numbers expressed as log10 per 107 copy numbers β-actin. Values are expressed as medians and interquartile ranges. Analysis by Wilcoxon rank sum test between healthy controls, patients with mild sepsis and severe sepsis day 1.

CytokineControlControl versus infectionInfectionInfection versus sepsis at ICU admissionSevere sepsis ICU admission

INFγ3ns2.8 2.3
2.7–3.32.6–3.21.8–2.6

TNF 4.5 4.9 4.5
4.3–4.94.5–5.54.3–5

IL22.8 2.3 2
2.5–3.12.2–2.61.6–2.2

IL73.8ns3.7 3.4
3.7–4.13.5–43.2–3.7

IL102.6 2.9 3.2
2.4–2.72.8–3.22.9–3.5

IL235.1 4.8 4.5
5.0–5.44.6–5.14.3–4.8

IL272.5 3ns3.1
2.3–2.72.8–3.32.7–3.4