Are Onconeural Antibodies a Clinical Phenomenology in Paraneoplastic Limbic Encephalitis?

Table 4

The common antibodies detected in PNS and their associated tumors.

Antibodies	PNS	Associated tumors
Antibodies against intracellular antigens
Anti-Hu	sensory neuronopathy, LE, BSE, encephalomyelitis	SCLC
Anti-Yo	SCD	Gynecological cancer
Anti-Ri	Opsoclonus-myoclonus, BSE	Breast cancer
Anti-Ma2	BSE, LE	Testis cancer, SCLC, breast cancer
Anti-CRMP5	SCD, chorea, myelitis, LE, sensory neuronopathy, optic neuritis	SCLC, thymoma
Anti-amphiphysin	SPS, myelitis, SCD, sensory neuronopathy	SCLC, breast cancer
Anti-GAD-65	SPS, myelitis	SCLC, breast cancer
Anti-SOX-1	LEMS	SCLC
Antibodies against cell surface onconeural antigens
Anti-VGCC	SPS, LEMS	SCLC
Anti-VGKC complex	LE	SCLC, thymoma
Anti-NMDA receptor	LE	Teratoma
Anti-AMPA receptor	LE	SCLC, breast cancer, thymoma
Anti-AQP-4	NMO spectrum disorders	SCLC, breast cancer, thymoma
Anti-GABA-B receptor	LE	SCLC
Anti-CAR	Retinopathy	SCLC, melanoma, gynecological cancer
Anti-contactin-associated protein 2	Morvan syndrome	Thymoma
Anti-AchR/MuSK/RyR/Titin	MG	Thymoma

AMPA: amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; AQP-4: aquaporin 4; CAR: cancer-associated retinopathy; CRMP5: collapsin response mediator protein 5; GABA-B: gamma-aminobutyric acid B; GAD-65: glutamic acid decarboxylase 65; LE: limbic encephalitis; LEMS: Lambert-Eaton myasthenic syndrome; MG: myasthenia gravis; NMDA: N-methyl-D-aspartate; NMO: neuromyelitis optica; SCD: subacute cerebellar degeneration; SCLC: small cell lung cancer; SPS: stiff-person syndrome; VGCC: voltage-gated calcium channel; VGKC: voltage-gated potassium channel.