Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent

Figure 2

Leukocyte infiltration after myocardial ischemia (30 min) and reperfusion (24 hrs). Box A reduced leukocyte infiltration in WT animals, while it had no effect in TLR2^−/− animals. HMGB1 injection did not affect leukocyte infiltration in both WT and TLR2^−/−. ^∗𝑃<0.05.