Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent
Leukocyte infiltration after myocardial ischemia (30 min) and reperfusion (24 hrs). Box A reduced leukocyte infiltration in WT animals, while it had no effect in TLR2−/− animals. HMGB1 injection did not affect leukocyte infiltration in both WT and TLR2−/−. .
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