Mediators of Inflammation / 2013 / Article / Fig 5

Research Article

Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice

Figure 5

LHVS suppresses the upregulation of proinflammatory cytokines (IL-1β and TNF-α) in the ipsilateral cortex at 24 h after traumatic brain injury (TBI). (a) IL-1β concentration was increased significantly in the TBI and TBI + vehicle groups compared with that in the sham group. Pretreatment with LHVS significantly attenuated IL-1β levels in the ipsilateral cortex compared with vehicle pretreatment. (b) TNF-α concentration was increased significantly in the TBI and TBI + vehicle groups compared with that in the sham group. Pretreatment with LHVS significantly attenuated TNF-α levels in the ipsilateral cortex compared with vehicle pretreatment. Data are presented as mean ± SEM ( ). *** , ** versus sham group; # , ## versus TBI + vehicle group.
187873.fig.005a
(a)
187873.fig.005b
(b)

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