Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice

Figure 6

LHVS reduces cerebral edema in the ipsilateral cortex 24 h after traumatic brain injury (TBI). Brain water content was significantly higher in the TBI and TBI + vehicle groups than in the sham group. Pretreatment with LHVS significantly attenuated brain water content in the ipsilateral cortex compared with vehicle pretreatment. Data are presented as mean ± SEM. **𝑃<0.01, ***𝑃<0.001 versus sham group (𝑛=5); ^#𝑃<0.05 versus TBI + vehicle group.