Mediators of Inflammation / 2013 / Article / Fig 7

Research Article

Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice

Figure 7

LHVS pretreatment reduces neuronal degeneration after traumatic brain injury (TBI). Upper panel: Fluoro-Jade C (FJC) staining of the pericontusional cortex in the sham group (a), TBI group (b), TBI + vehicle group (c), and TBI + LHVS (30 nM) group (d). Bottom panel: quantification of neurodegenerating (FJC-positive) cells in each group ( mice per group). Pretreatment with 30 nM LHVS significantly reduced the number of degenerating neurons at 24 h after TBI. Vehicle treatment had no effect. Data are presented as mean ± SEM ( ). *** versus sham group; # versus TBI + vehicle group. Scale bar: 20 µm.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.