Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice
LHVS pretreatment reduces neuronal degeneration after traumatic brain injury (TBI). Upper panel: Fluoro-Jade C (FJC) staining of the pericontusional cortex in the sham group (a), TBI group (b), TBI + vehicle group (c), and TBI + LHVS (30 nM) group (d). Bottom panel: quantification of neurodegenerating (FJC-positive) cells in each group ( mice per group). Pretreatment with 30 nM LHVS significantly reduced the number of degenerating neurons at 24 h after TBI. Vehicle treatment had no effect. Data are presented as mean ± SEM (). *** versus sham group; # versus TBI + vehicle group. Scale bar: 20 µm.
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