Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice
Neurological severity score (NSS) and grip test. (a) At 24 h after traumatic brain injury (TBI), mice pretreated with LHVS had significantly better neurological function than did mice pretreated with vehicle, as assessed by the NSS (a) and the grip test (b). At 3 days after TBI, function had improved in both groups. At this time point, neurological function was still slightly better in the LHVS-pretreated group, but the difference was significant only in the grip test. Data are presented as mean ± SEM (). *, *** versus TBI + vehicle; two-way ANOVA followed by Bonferroni post hoc test.
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