In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction
Figure 2
(a) Body temperature of WT- and TLR9-D mice 6 h after stimulation with the TLR9 agonist 1668-thioate. The TLR9 inhibitor H154-thioate was administered 30 min after stimulation. PBS application served as control. Bars of TLR9-D are striated (mean ± SEM; /group, *; *also indicates the significant group). (b) Survival over time of WT mice after stimulation with the TLR9 agonist 1668-thioate alone or in combination with the control ODN 1612-thioate or the TLR9 inhibitors H154- and IRS954-thioate as well as chloroquine. Inhibitors were injected i.v. 30 min after stimulation. PBS application served as control (/group).
