Mediators of Inflammation / 2013 / Article / Tab 1 / Review Article
Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches Table 1 Effects of different cytokines on neurogenesis.
Cytokine Effects on neurogenesis References IL-1α Increased astrocyte lineage [41 ] IL-1β Stimulation of NPCs proliferation and differentiation Decreased proliferation, survival, and neuronal differentiation Increased astrocyte differentiation [42 ] [43 ] [44 ] IL-4 Increased oligodendrogenesis [45 ] IL-6 Decreased proliferation, survival, and neuronal differentiation
[46 ] [47 ] [48 ] [49 ] Differentiation of NSC to neuronal lineages Increased neurogenesis IL-10 Increased proliferation [50 ] [51 ] IL-18 Decreased survival Increased neuronal differentiation [52 ] IFN-γ Decreased proliferation and survival of multipotent progenitors Promotion of differentiation and neurite outgrowth [53 ] [54 ] [55 ] CCL11 (eotaxin-1) Decreased Sox-2 progenitors, proliferation, and neuronal differentiation [28 ] CX3CL1 (fractalkine) Decreased neurogenesis [56 ] GM-CSF Stimulation of NPCs differentiation [57 ] G-CSF Promotes NPCs differentiation [27 ] TGF-β Decreased proliferation Increased survival and neural differentiation [58 ] [59 ] [60 ]