Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis

Figure 4

Comparison of inflammatory parameters in WT and TLR9-D mice. (a)–(h) Cardiac cytokine and TLR mRNA expressions were compared between WT Sham, WT CASP, and TLR9-D CASP hearts 18 h after surgery (*:𝑃<0.05; 𝑛=10/group; mean  ±  SEM). (i) Quantification of MAC-2-positive macrophages in immunohistochemically stained sections of the heart of control and CASP mice 6 h, 18 h, and 36 h after surgery (WT: white bars; TLR9-D: black bars; *:𝑃<0.05 versus respective control; 𝑛=6/group; mean  ±  SEM).

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