Mediators of Inflammation / 2013 / Article / Fig 12

Research Article

Dose-Dependent Anti-Inflammatory and Neuroprotective Effects of an ανβ3 Integrin-Binding Peptide

Figure 12

C16 treatment reduced the loss of neurons both in spinal cord and brain. Nissl staining; bar = 100 μm. ((a), (c), (e), (g), (i), (k), (m), and (o) coronal sections of motor cortex; (b), (d), (f), (h), (j), (l), (n), and (p) traverse section through the lumbar spinal cord). At week 2 after immunization, normal rats group ((a), (b)), vehicle control rats ((c), (d)), 2 mg/per day C16 treated EAE rats ((e), (f)), and C16 late treated EAE rats ((g), (h)). At week 8 after immunization, vehicle control rats ((i), (j)), 0.5 mg/per day C16 treated EAE rats ((k), (l)), 2 mg/per day C16 treated EAE rats ((m), (n)), and C16 late treated EAE rats ((o), (p)). (q) C16 treatment increased the surviving neural cells (% of the normal rats) in different dose groups, calculated after Nissl staining. versus normal rats; versus vehicle control rats at week 2 postimmunization group; versus vehicle control rats at week 8 after immunization. versus 0.5 mg/per day C16 treated EAE rats at week 8 after immunization. (r) Late treated C16 treatment also lessened the loss of neurons to a certain extent. versus normal rats; versus vehicle control rats at week 2 postimmunization group; versus C16 treated EAE rats at week 2 postimmunization group; versus vehicle control rats at week 8 after immunization.
268486.fig.0012a
(a)
268486.fig.0012b
(b)
268486.fig.0012c
(c)
268486.fig.0012d
(d)
268486.fig.0012e
(e)
268486.fig.0012f
(f)
268486.fig.0012g
(g)
268486.fig.0012h
(h)
268486.fig.0012i
(i)
268486.fig.0012j
(j)
268486.fig.0012k
(k)
268486.fig.0012l
(l)
268486.fig.0012m
(m)
268486.fig.0012n
(n)
268486.fig.0012o
(o)
268486.fig.0012p
(p)
268486.fig.0012q
(q)
268486.fig.0012r
(r)

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.