Mediators of Inflammation / 2013 / Article / Fig 13

Research Article

Dose-Dependent Anti-Inflammatory and Neuroprotective Effects of an ανβ3 Integrin-Binding Peptide

Figure 13

C16 treatment reduced TNF-α expression both in spinal cord and brain. TNF-α immunostaining, counterstained with hematoxylin; bar = 100 μm. ((a), (c), (e), (g), (i), (k), and (m) Coronal sections of motor cortex; (b), (d), (f), (h), (j), (l), and (n) traverse section through the lumbar spinal cord). At 2 weeks after immunization: vehicle control rats ((a), (b) plenty of TNF-α labeled apoptotic neural cells appeared in motor cortex and spinal cord anterior horn), 2 mg/per day C16 treated EAE rats ((c), (d)), and C16 late treated EAE rats ((e), (f)). At week 8 after immunization, vehicle control rats ((g), (h)), 2 mg/per day C16 treated EAE rats ((i), (j)), and C16 late treated EAE rats ((k), (l)). (k) Medium to high-dose C16 treatment reduced TNF-α labeled cells at 2 weeks postimmunization group, versus normal rats; versus vehicle control rats, versus 0.5 mg/per day C16 treated EAE rats. At week 8 after immunization, versus vehicle control rats, versus 0.5 mg/per day C16 treated EAE rats, and versus 1 mg/per day C16 treated EAE rats. (l) Late treated C16 treatment also decreased TNF-α labeled cells to a certain extent. versus normal rats; versus vehicle control rats at week 2 after immunization; versus C16 treated EAE rats at week 2 after immunization; versus vehicle control rats at week 8 after immunization.
268486.fig.0013a
(a)
268486.fig.0013b
(b)
268486.fig.0013c
(c)
268486.fig.0013d
(d)
268486.fig.0013e
(e)
268486.fig.0013f
(f)
268486.fig.0013g
(g)
268486.fig.0013h
(h)
268486.fig.0013i
(i)
268486.fig.0013j
(j)
268486.fig.0013k
(k)
268486.fig.0013l
(l)
268486.fig.0013m
(m)
268486.fig.0013n
(n)

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.