Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2013, Article ID 268486, 24 pages
http://dx.doi.org/10.1155/2013/268486
Research Article

Dose-Dependent Anti-Inflammatory and Neuroprotective Effects of an ανβ3 Integrin-Binding Peptide

1Institute of Neuroscience, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, China
2Department of Obstetrics and Gynecology, Hangzhou Red Cross Hospital, Hangzhou 310003, China
3Zhejiang University School of Medicine, Hangzhou 310058, China
4Brain Research Center, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong

Received 20 June 2013; Revised 4 September 2013; Accepted 5 September 2013

Academic Editor: Vera L. Petricevich

Copyright © 2013 Shu Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-X. Yin, J.-L. Tu, H.-J. Lin et al., “Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model,” PLoS ONE, vol. 5, no. 8, Article ID e12400, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Stanislaus, A. K. Singh, and I. Singh, “Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis,” Journal of Neuroscience Research, vol. 66, no. 2, pp. 155–162, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Arnon and R. Aharoni, “Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate,” Journal of Neural Transmission, vol. 116, no. 11, pp. 1443–1449, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Claudio, Y. Kress, W. T. Norton, and C. F. Brosnan, “Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis,” The American Journal of Pathology, vol. 135, no. 6, pp. 1157–1168, 1989. View at Google Scholar · View at Scopus
  5. C. Paul and C. Bolton, “Inhibition of blood-brain barrier disruption in experimental allergic encephalomyelitis by short-term. Therapy with dexamethasone or cyclosporin A,” International Journal of Immunopharmacology, vol. 17, no. 6, pp. 497–503, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Garay, M. C. G. Deniselle, A. Lima, P. Roig, and A. F. de Nicola, “Effects of progesterone in the spinal cord of a mouse model of multiple sclerosis,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 107, no. 3–5, pp. 228–237, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Garay, M. C. Gonzalez Deniselle, L. Gierman et al., “Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis,” NeuroImmunoModulation, vol. 15, no. 1, pp. 76–83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. B.-G. Xiao, Y.-M. Huang, L.-Y. Xu, M. Ishikawa, and H. Link, “Mechanisms of recovery from experimental allergic encephalomyelitis induced with myelin basic protein peptide 68-86 in Lewis rats: a role for dendritic cells in inducing apoptosis of CD4+ T cells,” Journal of Neuroimmunology, vol. 97, no. 1-2, pp. 25–36, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. X. Zhang, J. Reddy, H. Ochi, D. Frenkel, V. K. Kuchroo, and H. L. Weiner, “Recovery from experimental allergic encephalomyelitis is TGF-β dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells,” International Immunology, vol. 18, no. 4, pp. 495–503, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. M. P. Pender, “Recovery from acute experimental allergic encephalomyelitis in the Lewis rat. Early restoration of nerve conduction and repair by Schwann cells and oligodendrocytes,” Brain, vol. 112, part 2, pp. 393–416, 1989. View at Google Scholar · View at Scopus
  11. V. Balasingam, T. Tejada-Berges, E. Wright, R. Bouckova, and V. W. Yong, “Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines,” Journal of Neuroscience, vol. 14, no. 2, pp. 846–856, 1994. View at Google Scholar · View at Scopus
  12. P. Bannerman, A. Hahn, A. Soulika, V. Gallo, and D. Pleasure, “Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia,” Glia, vol. 55, no. 1, pp. 57–64, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Alon and F. W. Luscinskas, “Crawling and INTEGRating apical cues,” Nature Immunology, vol. 5, no. 4, pp. 351–353, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Weerasinghe, K. P. McHugh, F. P. Ross, E. J. Brown, R. H. Gisler, and B. A. Imhof, “A role for the αvβ3 integrin in the transmigration of monocytes,” The Journal of Cell Biology, vol. 142, no. 2, pp. 595–607, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Fang, Y. Sun, Z. Hu et al., “C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model,” Neuropharmacology, vol. 70, pp. 83–99, 2013. View at Google Scholar
  16. S. Han, S. A. Arnold, S. D. Sithu et al., “Rescuing vasculature with intravenous angiopoietin-1 and αvβ3 integrin peptide is protective after spinal cord injury,” Brain, vol. 133, part 4, pp. 1026–1042, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. L. Ponce, M. Nomizu, M. C. Delgado et al., “Identification of endothelial cell binding sites on the laminin γ1 chain,” Circulation Research, vol. 84, no. 6, pp. 688–694, 1999. View at Google Scholar · View at Scopus
  18. M. J. Carson, “Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis,” Glia, vol. 40, no. 2, pp. 218–231, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Raivich and R. Banati, “Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease,” Brain Research Reviews, vol. 46, no. 3, pp. 261–281, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. K. A. Naidu, E. S. Fu, and L. D. Prockop, “Acute experimental allergic encephalomyelitis increases lumbar spinal cord incorporation of epidurally administered [3H]-D-mannitol and [14C]-carboxyl-inulin in rabbits,” Anesthesia and Analgesia, vol. 94, no. 1, pp. 208–212, 2002. View at Google Scholar · View at Scopus
  21. H.-J. Yu, J. Fei, X.-S. Chen et al., “Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein,” Neuroscience Letters, vol. 476, no. 1, pp. 42–45, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. X. Ma, Y. Jiang, A. Wu et al., “Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice,” PLoS ONE, vol. 5, no. 10, Article ID e13489, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Fang, J.-Y. Huang, J. Wang et al., “Anti-neuroinflammatory and neurotrophic effects of combined therapy with annexin II and Reg-2 on injured spinal cord,” NeuroSignals, vol. 19, no. 1, pp. 16–43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Bhasin, M. Wu, and S. E. Tsirka, “Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis,” BMC Immunology, vol. 8, article 10, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. E. D. Ponomarev, L. P. Shriver, K. Maresz, J. Pedras-Vasconcelos, D. Verthelyi, and B. N. Dittel, “GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis,” Journal of Immunology, vol. 178, no. 1, pp. 39–48, 2007. View at Google Scholar · View at Scopus
  26. V. Dousset, R. I. Grossman, K. N. Ramer et al., “Experimental allergic encephalomyelitis and multiple sclerosis: Lesion characterization with magnetization transfer imaging,” Radiology, vol. 182, no. 2, pp. 483–491, 1992. View at Google Scholar · View at Scopus
  27. S. J. Kent, S. J. Karlik, C. Cannon et al., “A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis,” Journal of Neuroimmunology, vol. 58, no. 1, pp. 1–10, 1995. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Ichioka, N. Sekiya, M. Shibata, and T. Nakatsuka, “AlphaV beta3 (αvβ3) integrin inhibition reduces leukocyte-endothelium interaction in a pressure-induced reperfusion model,” Wound Repair and Regeneration, vol. 15, no. 4, pp. 572–576, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. A. S. Antonov, G. N. Antonova, D. H. Munn et al., “αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation,” Journal of Cellular Physiology, vol. 226, no. 2, pp. 469–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Hellings, J. Raus, and P. Stinissen, “Insights into the immunopathogenesis of multiple sclerosis,” Immunologic Research, vol. 25, no. 1, pp. 27–51, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Z. Liu, X. M. Xu, R. Hu et al., “Neuronal and glial apoptosis after traumatic spinal cord injury,” Journal of Neuroscience, vol. 17, no. 14, pp. 5395–5406, 1997. View at Google Scholar · View at Scopus
  32. M. J. Crowe, J. C. Bresnahan, S. L. Shuman, J. N. Masters, and M. S. Beattie, “Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys,” Nature Medicine, vol. 3, no. 1, pp. 73–76, 1997. View at Google Scholar
  33. P. Warden, N. I. Bamber, H. Li et al., “Delayed glial cell death following Wallerian degeneration in white matter tracts after spinal cord dorsal column cordotomy in adult rats,” Experimental Neurology, vol. 168, no. 2, pp. 213–224, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Profyris, S. S. Cheema, D. Zang, M. F. Azari, K. Boyle, and S. Petratos, “Degenerative and regenerative mechanisms governing spinal cord injury,” Neurobiology of Disease, vol. 15, no. 3, pp. 415–436, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Garay, M. C. Gonzalez Deniselle, L. Gierman et al., “Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis,” NeuroImmunoModulation, vol. 15, no. 1, pp. 76–83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Kerschensteiner, C. Stadelmann, B. S. Buddeberg et al., “Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis,” The American Journal of Pathology, vol. 164, no. 4, pp. 1455–1469, 2004. View at Google Scholar · View at Scopus
  37. B. Almolda, M. Costa, M. Montoya, B. González, and B. Castellano, “Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat,” PLoS ONE, vol. 6, no. 11, Article ID e27473, 2011. View at Publisher · View at Google Scholar · View at Scopus