Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice
Figure 2
Peripheral LPS injection (0.63 mg/kg, i.p.) increased IBA1 immunoreactivity, a marker of microglial activation, in the hippocampal dentate gyrus at 24 h after administration. Representative images (10x) (a), quantified images of per group (b). Graph is plotted as mean + SEM. Data were analyzed by ANOVA followed by independent samples t-test. *** compared to vehicle.
