Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

Figure 4

Intraperitoneal injection of LPS caused sickness, but no clear depressive-like behavior is observed. Peripheral immune activation caused a dose- and time-dependent reduction in locomotor activity in the open field test (OFT). However, a single i.p. injection of LPS did not induce clear anxiety or depressive-like behavior in the stress-induced hyperthermia (SIH) test, tail suspension test (TST), or forced swim test (FST). Graphs are plotted as mean + SEM (𝑛=10 per group). Data were analyzed by multivariate ANOVA followed by independent samples t-test. *𝑃<0.05 compared to 0 mg/kg LPS group, ^(*)0.05 > 𝑃>0.1 compared to 0 mg/kg LPS group, ^#𝑃<0.05 compared to Temp1 (SIH) ^(#)0.05>𝑃>0.1 compared to Temp1 (SIH).